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Proteomics is the study of the complete set of proteins that is expressed at a given time in a cell, tissue, organ or organism, i.e. the proteome. There is a general interest to proteomics in life sciences, since when compared to e.g. genomics/functional genomics, proteomics provides a much more complete understanding of the studied biological system. Due to events such as alternative splicing and post-translational modifications (i.e. phosphorylation, glycosylation, ubiquitinylation, myristoylation, palmitoylation etc.), the number of different proteins expressed in an organism is by far greater than the number of its functional genes.

In most cases, changes at protein level determine the differences between sickness and health and can be used to monitor the progression of disease. Almost all drugs on the market and those under development act by trying to alter a protein (mal)function. Therefore, typically one of the first steps in a drug discovery project is the identification and validation of the protein target(s) or markers associated with a disease (one type of biomarkers).

We offer our customers a wide spectrum of proteomics expertise and services, based on bidimensional electrophoresis, coupled with bioinformatics and image analysis. The samples can be fluids, like serum, plasma, urine, cell lysates or solid tissue samples as well as processed samples like SDS gel plugs. NanoLC-MS/MS for protein/peptide identification can be subcontracted.